Key Takeaways
The four components below are essential for campaigns designed to influence prescribing behavior:
- The Right Audience: Use prescribing, diagnosis, and procedural data to reach providers actively treating your condition.
- Reach: Most impressions occur on mobile, in-app, and across display, video, and native channels.
- Insights: Go beyond clicks by using pixel data to track return visits and link engagement to NPI-level activity.
- Time: Plan for 12 to 16 weeks to build frequency, retarget effectively, and drive measurable script lift.
1. Start with the Right Audience
Many campaigns begin with targeting, but static specialty lists often fall short. They miss the nuance of real-time clinical activity and fail to capture true prescribing intent. To drive meaningful change, targeting must reflect what HCPs are doing, not just who they are.
High-performing campaigns focus on HCPs who are:
- Actively treating patients within the relevant therapy area
- Writing prescriptions or making diagnoses that align with your brand
- Performing procedures connected to your treatment pathway
The chart below shows how behavioral filters refine a broad HCP pool into a high-intent audience. From 100,000+ potential HCPs, layers of clinical activity narrow the group to those most likely to engage, based on recent treatments, prescribing history, and procedure data.
This approach ensures your media budget reaches the most relevant HCPs, improving campaign precision and impact.

The most effective strategies use multi-payer claims data to build dynamic, NPI-level segments that are refreshed regularly to reflect evolving clinical patterns.
When audiences are based on real-world activity, campaigns deliver stronger relevance, higher engagement, and more measurable outcomes.
2. Plan Channel Mix to Maximize Reach
Maximizing reach and frequency requires more than just increased spend. Campaigns must be planned around how HCPs actually consume content across devices and platforms.
Trade Desk data (Q2 2025) shows that over 50 percent of impressions are served on mobile, and 84 percent appear in-app. Most inventory is split across display (55 percent), video (20 percent), and native (16 percent) formats.
To reach HCPs effectively, campaigns should:
- Use at least five formats to diversify delivery and increase touchpoints
- Prioritize mobile-first and responsive creative
- Include display banners, short-form video, and native formats
- Optimize placements for in-app environments

Source: Addressable media mix for 1.3M U.S. physicians via Trade Desk, Q2 2025.
This approach ensures content appears where and how HCPs are most likely to engage, resulting in better delivery, stronger frequency control, and higher overall impact.
3. Track Behavior Beyond the Click
Click metrics only capture surface-level interaction. To influence prescribing decisions, campaigns must measure how HCPs engage after exposure.
That begins with a website pixel.
A well-placed pixel allows marketers to monitor:
- Page views, scroll depth, and time spent on key content
- Return visits across multiple sessions
- View-through conversions that occur without direct interaction
When paired with NPI-level targeting, this behavioral data becomes actionable. Marketers can link activity back to individual HCPs, identify high-intent behaviors, and optimize messaging accordingly.
Wrango’s data shows that desktop users are twice as likely to return to site content compared to mobile users. This trend is especially strong among physicians and nurse practitioners, indicating deeper research behavior on desktop.

By focusing on meaningful signals, not just clicks, marketers can make better decisions and strengthen campaign performance throughout the HCP journey.
4. Give it Time to Work
Prescribing behavior evolves gradually. It is shaped through repeated exposure, message reinforcement, and trust over time. Short campaigns often underperform because they do not align with how HCPs make clinical decisions.
To drive measurable script lift, campaigns must be given enough time to build frequency, sequence messaging, and re-engage interested HCPs.
Running a campaign for 12 to 16 weeks allows for:
- Sequenced messaging across the decision journey
- Strategic retargeting of engaged NPIs
- Sustained exposure that builds familiarity and recall
When combined with intent-based targeting and omnichannel media, longer campaigns show compounding effects. Over time, consistent engagement strengthens brand perception and increases the likelihood of influencing prescribing choices.
Giving a campaign time to run its full course ensures alignment with real-world clinical decision-making patterns.

Final Thoughts
When campaigns are grounded in real-world behavior, delivered through relevant channels, measured with purpose, and given time to resonate, influencing prescribing becomes a repeatable outcome.
By applying these principles, marketers can move beyond impressions and begin shaping the decisions that ultimately improve patient care.